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Aricept (Donepezil)

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Aricept (Donepezil) is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct donepezil's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact.

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About Aricept (Donepezil):

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Brand name: Aricept Generic name: Donepezil What is Aricept (Donepezil)? Aricept improves the function of nerve cells in the brain. It works by preventing the breakdown of a chemical called acetylcholine (ah see til KO leen). People with dementia usually have lower levels of this chemical which is important for the processes of memory thinking and reasoning. Aricept is used to treat mild to moderate dementia caused by Alzheimer's disease. Aricept may also be used for other purposes not listed in this medication guide. What is the most important information I should know about donepezil? Before taking donepezil tell your doctor if you have a heart rhythm disorder such as "sick sinus syndrome" (slow heartbeats) an enlarged prostate urination problems asthma obstructive pulmonary disease or a seizure disorder such as epilepsy. If you need to have any type of surgery tell the surgeon ahead of time that you are taking donepezil. Aricept can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. What should I discuss with my healthcare provider before taking donepezil? Do not take this medication if you are allergic to donepezil. Before taking donepezil tell your doctor if you are allergic to any drugs or if you have: • a heart rhythm disorder such as "sick sinus syndrome" (slow heartbeats); • a history of stomach ulcers; • an enlarged prostate or urination problems; • epilepsy or other seizure disorder; or • asthma or chronic obstructive pulmonary disease (COPD). If you have any of these conditions you may need a dose adjustment or special tests to safely take donepezil. FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether donepezil passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I take donepezil? Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts or take it for longer than recommended by your doctor. Follow the directions on your prescription label. If you need to have any type of surgery tell the surgeon ahead of time that you are taking donepezil. You may need to stop using the medicine for a short time. Aricept can be taken with or without food or milk. Take the donepezil regular tablets with a full glass of water. To take donepezil orally disintegrating tablet (Aricept ODT): • Keep the tablet in its blister pack until you are ready to take the medicine. Open the package and peel or cut the backing from the tablet blister. Do not push a tablet through the backing or you may damage the tablet. • Using dry hands remove the tablet and place it in your mouth. It will begin to dissolve right away. • Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. • Swallow several times as the tablet dissolves. After the tablet dissolves completely drink a glass of water. Aricept is usually taken at bedtime. Follow your doctor's instructions. Store donepezil at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. If it is almost time for your next dose skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include severe nausea vomiting drooling sweating blurred vision feeling light-headed slow heartbeat shallow breathing muscle weakness fainting or seizure (convulsions). What should I avoid while taking donepezil? Aricept can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Aricept side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face lips tongue or throat. Stop using donepezil and call your doctor at once if you have any of these serious side effects: • black bloody or tarry stools; • coughing up blood or vomit that looks like blood or coffee grounds; • painful or difficult urination; • seizure (black-out or convulsions); Less serious side effects may include: • nausea vomiting diarrhea; • loss of appetite; • muscle cramps; • tired feeling; or • sleep problems (insomnia). This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. What other drugs will affect donepezil? Before taking donepezil tell your doctor if you are taking any of the following medicines: • atropine (Donnatal and others); • belladonna; • carbamazepine (Tegretol); • clidinium (Quarzan); • dexamethasone (Decadron); • dicyclomine (Bentyl); • glycopyrrolate (Robinul); • hyoscyamine (Anaspaz Cystospaz Levsin and others); • mepenzolate (Cantil); • methantheline (Provocholine); • methscopolamine (Pamine) scopolamine (Transderm-Scop); • phenobarbital (Luminal Solfoton); • phenytoin (Dilantin); • propantheline (Pro-Banthine); • quinidine (Cardioquin Quinidex Quinaglute others); • rifampin (Rifadin Rifamate Rifater); • a fungal antibiotic such as ketoconazole (Nizoral) fluconazole (Diflucan) or itraconazole (Sporanox); or • aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin Advil) naproxen (Aleve Naprosyn) diclofenac (Voltaren) diflunisal (Dolobid) etodolac (Lodine) flurbiprofen (Ansaid) indomethacin (Indocin) ketoprofen (Orudis) ketorolac (Toradol) mefenamic acid (Ponstel) meloxicam (Mobic) nabumetone (Relafen) piroxicam (Feldene) and others. This list is not complete and there may be other drugs that can interact with donepezil. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins minerals herbal products and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Discount Prescription Drugs & Pain Medicine: Anaprox (Naproxen) Anaprox (Naproxen) is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and swelling (inflammation). It is also used to treat headaches muscle aches backaches etc. Buy Anaprox (Naproxen) and other Pain Medicine products online at Medstore. About Anaprox (Naproxen): Product Type: Pain Medicine Brand name: Anaprox Generic name: Naproxen What is anaprox? Naproxen is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Naproxen works by reducing hormones that cause inflammation and pain in the body. Naproxen is used to treat pain or inflammation caused by conditions such as arthritis ankylosing spondylitis tendinitis bursitis gout or menstrual cramps. Naproxen may also be used for purposes other than those listed in this medication guide. What is the most important information I should know about anaprox? This medicine can increase your risk of life-threatening heart or circulation problems including heart attack or stroke. This risk will increase the longer you use anaprox. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft or CABG). Seek emergency medical help if you have symptoms of heart or circulation problems such as chest pain weakness shortness of breath slurred speech or problems with vision or balance. This medicine can also increase your risk of serious effects on the stomach or intestines including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking anaprox. Older adults may have an even greater risk of these serious gastrointestinal side effects. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black bloody or tarry stools or coughing up blood or vomit that looks like coffee grounds. Do not use any other over-the-counter cold allergy or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to anaprox (such as ibuprofen or ketoprofen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin ibuprofen or ketoprofen. Do not drink alcohol while taking anaprox. Alcohol can increase the risk of stomach bleeding caused by anaprox. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Naproxen can make your skin more sensitive to sunlight and sunburn may result. What should I discuss with my healthcare provider before taking anaprox? Taking an NSAID can increase your risk of life-threatening heart or circulation problems including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft or CABG). NSAIDs can also increase your risk of serious effects on the stomach or intestines including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects. Do not use this medication if you are allergic to anaprox or if you have a history of allergic reaction to aspirin or other NSAIDs. Before taking anaprox tell your doctor if you are allergic to any drugs or if you have: • a history of heart attack stroke or blood clot; • heart disease congestive heart failure high blood pressure; • a history of stomach ulcers or bleeding; • liver or kidney disease; • asthma; • polyps in your nose; • a bleeding or blood clotting disorder; or • if you smoke. If you have any of these conditions you may not be able to use anaprox or you may need a dosage adjustment or special tests during treatment. FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking anaprox during the last 3 months of pregnancy may result in birth defects. Do not take anaprox during pregnancy unless your doctor has told you to. Naproxen can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medicine to a child younger than 2 years old without the advice of a doctor. How should I take anaprox? Take this medication exactly as directed on the label or as it has been prescribed by your doctor. Do not use the medication in larger amounts or use it for longer than recommended. EC-Naprosyn is a slower-acting form of anaprox and this brand should be used only for treating arthritis or ankylosing spondylitis. Follow your doctor's instructions. Do not crush chew or break an extended-release or enteric-coated tablet. Swallow the pill whole. The extended-release pill is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time. The enteric-coated pill has a special coating to protect your stomach. Breaking the pill could damage this coating. Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose measure the liquid with a marked measuring spoon or medicine cup not with a regular table spoon. If you do not have a dose-measuring device ask your pharmacist for one. If you take anaprox for a long period of time your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor. Store anaprox at room temperature away from moisture and heat. What happens if I miss a dose? Since anaprox is sometimes taken as needed you may not be on a dosing schedule. If you are taking the medication regularly take the missed dose as soon as you remember. If it is almost time for your next dose skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a anaprox overdose may include nausea vomiting stomach pain confusion drowsiness black or bloody stools coughing up blood shallow breathing fainting or coma. What should I avoid while taking anaprox? Do not use any other over-the-counter cold allergy or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to anaprox (such as ibuprofen or ketoprofen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin ibuprofen or ketoprofen. Do not drink alcohol while taking anaprox. Alcohol can increase the risk of stomach bleeding caused by anaprox. Avoid prolonged exposure to sunlight. Naproxen may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable. Naproxen side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face lips tongue or throat. Stop taking anaprox and seek medical attention or call your doctor at once if you have any of these serious side effects: • chest pain weakness shortness of breath slurred speech problems with vision or balance; • black bloody or tarry stools; • coughing up blood or vomit that looks like coffee grounds; • swelling or rapid weight gain; • urinating less than usual or not at all; • nausea stomach pain low fever loss of appetite dark urine clay-colored stools jaundice (yellowing of the skin or eyes); • fever sore throat and headache with a severe blistering peeling and red skin rash; • bruising severe tingling numbness pain muscle weakness; or • fever headache neck stiffness chills increased sensitivity to light purple spots on the skin and/or seizure (convulsions). Keep taking anaprox and talk to your doctor if you have any of these less serious side effects: • upset stomach mild heartburn or stomach pain diarrhea constipation; • bloating gas; • dizziness headache nervousness; • skin itching or rash; • blurred vision; or • ringing in your ears. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect anaprox? Before taking anaprox tell your doctor if you are taking any of the following drugs: • a blood thinner such as warfarin (Coumadin); • lithium (Eskalith Lithobid); • methotrexate (Rheumatrex Trexall); • diuretics (water pills) such as furosemide (Lasix); • steroids (prednisone and others); • aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as diclofenac (Cataflam Voltaren) etodolac (Lodine) flurbiprofen (Ansaid) indomethacin (Indocin) ketoprofen (Orudis) ketorolac (Toradol) mefenamic acid (Ponstel) meloxicam (Mobic) nabumetone (Relafen) piroxicam (Feldene) and others; or • an ACE inhibitor such as benazepril (Lotensin) captopril (Capoten) fosinopril (Monopril) enalapril (Vasotec) lisinopril (Prinivil Zestril) ramipril (Altace) and others. If you are using any of these drugs you may not be able to use anaprox or you may need dosage adjustments or special tests during treatment. There may be other drugs not listed that can affect anaprox. 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