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Methotrexate

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Methotrexate is an antimetabolite used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis. This medicine works by interfering with cell growth and by suppressing the immune system. Early treatment of rheumatoid arthritis with more aggressive therapy such as methotrexate helps to reduce further joint damage and to preserve joint function. This medicine may also be used to treat other conditions as determined by your doctor including lupus and psoriatic arthritis.

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About Methotrexate:

Product Type: Cancer

Brand name: Methotrexate What is methotrexate? Methotrexate interferes with the growth of certain cells of the body especially cells that reproduce quickly such as cancer cells bone marrow cells and skin cells. Methotrexate is used to treat certain types of cancer of the breast skin head and neck or lung. Methotrexate is also used to treat severe psoriasis and rheumatoid arthritis. Methotrexate is usually given after other medications have been tried without successful treatment of symptoms. Methotrexate may also be used for other purposes not listed in this medication guide. What is the most important information I should know about methotrexate? Methotrexate can cause serious or life-threatening side effects on your liver lungs kidneys and bone marrow (immune system). Do not take this medication in larger amounts or take it for longer than prescribed. Follow the directions on your prescription label. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you have liver disease (especially if caused by alcoholism) a blood cell or bone marrow disorder or if you are breast-feeding a baby. This medication can cause birth defects in an unborn baby. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you are pregnant. Use an effective form of birth control whether you are a man or a woman. Tell your doctor if you or your sexual partner become pregnant during treatment. To be sure this medication is not causing harmful effects your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled appointments. There are many other medicines that can interact with methotrexate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins minerals herbal products and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you. What should I discuss with my healthcare provider before taking methotrexate? Do not use this medication if you are allergic to methotrexate. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you have: • liver disease; • alcoholism or cirrhosis of the liver; • a blood cell disorder such as anemia (lack of red blood cells) or leukopenia (lack of white blood cells); • a bone marrow disorder; or • if you are breast-feeding a baby. Methotrexate is sometimes used to treat cancer even when patients do have one of the conditions listed above. Your doctor will decide if this treatment is right for you. Before using methotrexate tell your doctor if you are allergic to any drugs or if you have: • kidney disease; • liver disease; • lung disease or pneumonia; • stomach ulcers; • any type of infection; or • if you are receiving radiation treatments. FDA pregnancy category X. Methotrexate can cause birth defects in an unborn baby. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use birth control to prevent pregnancy while you are using methotrexate whether you are a man or a woman. Methotrexate use by either parent may cause birth defects. Before you start taking methotrexate your doctor may want you to have a pregnancy test to make sure you are not pregnant. If you are a man use a condom to keep from causing a pregnancy while you are using methotrexate. Continue using condoms for at least 90 days after your treatment ends. If you are a woman use an effective form of birth control while you are taking methotrexate and for at least one cycle of ovulation after your treatment ends. Do not give this medicine to a child without the advice of a doctor. Older adults may be more likely to have side effects from this medication. How should I take methotrexate? Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts or take it for longer than recommended by your doctor. Follow the directions on your prescription label. You must use the correct dose of methotrexate for your condition. The medication is sometimes taken only once per week. Some people have died after taking methotrexate every day by accident. Ask your doctor if you have any questions about your dose of methotrexate or how often to take it. This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions. It is important to use methotrexate regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. To be sure this medication is not causing harmful effects your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested and you may need an occasional liver biopsy. Do not miss any scheduled appointments. Store methotrexate at room temperature away from moisture and heat. What happens if I miss a dose? Call your doctor if you miss a dose of methotrexate. What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine. An overdose of methotrexate can be fatal. Overdose symptoms may include pale skin easy bruising or bleeding unusual weakness mouth sores nausea vomiting black or bloody stools coughing up blood or vomit that looks like coffee grounds and urinating less than usual or not at all. What should I avoid while taking methotrexate? Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds) especially if you are being treated for psoriasis. Methotrexate can make your skin more sensitive to sunlight and your psoriasis may worsen. Avoid drinking alcohol while taking methotrexate. Methotrexate side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face lips tongue or throat. Stop using methotrexate and call your doctor at once if you have any of these serious side effects: • dry cough shortness of breath; • diarrhea vomiting white patches or sores inside your mouth or on your lips; • blood in your urine or stools; • urinating less than usual or not at all; • fever chills body aches flu symptoms; • sore throat and headache with a severe blistering peeling and red skin rash; • pale skin easy bruising or bleeding weakness; or • nausea stomach pain low fever loss of appetite dark urine clay-colored stools jaundice (yellowing of the skin or eyes). Less serious side effects may include: • nausea vomiting upset stomach; • dizziness tired feeling; • headache; • bleeding of your gums; or • blurred vision. This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. What other drugs will affect methotrexate? Before taking methotrexate tell your doctor if you are using any of the following drugs: • azathioprine (Imuran); • chloramphenicol (Chloromycetin); • hydroxychloroquine (Plaquenil Quineprox); • retinol tretinoin (Retin-A) isotretinoin (Accutane); • steroids (prednisone and others); • sulfa drugs such as Azulfidine Bactrim or Septra; • phenytoin (Dilantin); • probenecid (Benemid); • tetracycline (Brodspec Panmycin Sumycin Tetracap); • theophylline (Elixophyllin Slo-Bid Theobid Theo-Dur); • gold treatments such as auranofin (Ridura) or aurothioglucose (Solganol); • oral diabetes medications such as acetohexamide (Dymelor) chlorpropamide (Diabinese) glipizide (Glucotrol) glimepiride (Amaryl) or tolbutamide (Orinase); • penicillin antibiotic such as ampicillin (Principen) amoxicillin (Amoxil Trimox) carbenicillin (Geocillin) cloxacillin (Cloxapen) dicloxacillin (Dynapen) nafcillin (Unipen) oxacillin (Bactocill) penicillamine (Cuprimine Depen) or Bee-Pen Pen-Vee K Veetids; • salicylates such as aspirin Disalcid Doan's Pills Dolobid Salflex Tricosal and others; or • NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin Advil) naproxen (Aleve Naprosyn) diclofenac (Voltaren) diflunisal (Dolobid) etodolac (Lodine) flurbiprofen (Ansaid) indomethacin (Indocin) ketoprofen (Orudis) ketorolac (Toradol) mefenamic acid (Ponstel) meloxicam (Mobic) nabumetone (Relafen) piroxicam (Feldene) and others. This list is not complete and there may be other drugs that can interact with methotrexate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins minerals herbal products and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Discount Prescription Drugs & Pain Medicine: Anaprox (Naproxen) Anaprox (Naproxen) is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and swelling (inflammation). It is also used to treat headaches muscle aches backaches etc. Buy Anaprox (Naproxen) and other Pain Medicine products online at Medstore. About Anaprox (Naproxen): Product Type: Pain Medicine Brand name: Anaprox Generic name: Naproxen What is anaprox? Naproxen is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Naproxen works by reducing hormones that cause inflammation and pain in the body. Naproxen is used to treat pain or inflammation caused by conditions such as arthritis ankylosing spondylitis tendinitis bursitis gout or menstrual cramps. Naproxen may also be used for purposes other than those listed in this medication guide. What is the most important information I should know about anaprox? This medicine can increase your risk of life-threatening heart or circulation problems including heart attack or stroke. This risk will increase the longer you use anaprox. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft or CABG). Seek emergency medical help if you have symptoms of heart or circulation problems such as chest pain weakness shortness of breath slurred speech or problems with vision or balance. This medicine can also increase your risk of serious effects on the stomach or intestines including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking anaprox. Older adults may have an even greater risk of these serious gastrointestinal side effects. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black bloody or tarry stools or coughing up blood or vomit that looks like coffee grounds. Do not use any other over-the-counter cold allergy or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to anaprox (such as ibuprofen or ketoprofen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin ibuprofen or ketoprofen. Do not drink alcohol while taking anaprox. Alcohol can increase the risk of stomach bleeding caused by anaprox. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Naproxen can make your skin more sensitive to sunlight and sunburn may result. What should I discuss with my healthcare provider before taking anaprox? Taking an NSAID can increase your risk of life-threatening heart or circulation problems including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft or CABG). NSAIDs can also increase your risk of serious effects on the stomach or intestines including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects. Do not use this medication if you are allergic to anaprox or if you have a history of allergic reaction to aspirin or other NSAIDs. Before taking anaprox tell your doctor if you are allergic to any drugs or if you have: • a history of heart attack stroke or blood clot; • heart disease congestive heart failure high blood pressure; • a history of stomach ulcers or bleeding; • liver or kidney disease; • asthma; • polyps in your nose; • a bleeding or blood clotting disorder; or • if you smoke. If you have any of these conditions you may not be able to use anaprox or you may need a dosage adjustment or special tests during treatment. FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking anaprox during the last 3 months of pregnancy may result in birth defects. Do not take anaprox during pregnancy unless your doctor has told you to. Naproxen can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medicine to a child younger than 2 years old without the advice of a doctor. How should I take anaprox? Take this medication exactly as directed on the label or as it has been prescribed by your doctor. Do not use the medication in larger amounts or use it for longer than recommended. EC-Naprosyn is a slower-acting form of anaprox and this brand should be used only for treating arthritis or ankylosing spondylitis. Follow your doctor's instructions. Do not crush chew or break an extended-release or enteric-coated tablet. Swallow the pill whole. The extended-release pill is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time. The enteric-coated pill has a special coating to protect your stomach. Breaking the pill could damage this coating. Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose measure the liquid with a marked measuring spoon or medicine cup not with a regular table spoon. If you do not have a dose-measuring device ask your pharmacist for one. If you take anaprox for a long period of time your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor. Store anaprox at room temperature away from moisture and heat. What happens if I miss a dose? Since anaprox is sometimes taken as needed you may not be on a dosing schedule. If you are taking the medication regularly take the missed dose as soon as you remember. If it is almost time for your next dose skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a anaprox overdose may include nausea vomiting stomach pain confusion drowsiness black or bloody stools coughing up blood shallow breathing fainting or coma. What should I avoid while taking anaprox? Do not use any other over-the-counter cold allergy or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to anaprox (such as ibuprofen or ketoprofen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin ibuprofen or ketoprofen. Do not drink alcohol while taking anaprox. Alcohol can increase the risk of stomach bleeding caused by anaprox. Avoid prolonged exposure to sunlight. Naproxen may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable. Naproxen side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face lips tongue or throat. Stop taking anaprox and seek medical attention or call your doctor at once if you have any of these serious side effects: • chest pain weakness shortness of breath slurred speech problems with vision or balance; • black bloody or tarry stools; • coughing up blood or vomit that looks like coffee grounds; • swelling or rapid weight gain; • urinating less than usual or not at all; • nausea stomach pain low fever loss of appetite dark urine clay-colored stools jaundice (yellowing of the skin or eyes); • fever sore throat and headache with a severe blistering peeling and red skin rash; • bruising severe tingling numbness pain muscle weakness; or • fever headache neck stiffness chills increased sensitivity to light purple spots on the skin and/or seizure (convulsions). Keep taking anaprox and talk to your doctor if you have any of these less serious side effects: • upset stomach mild heartburn or stomach pain diarrhea constipation; • bloating gas; • dizziness headache nervousness; • skin itching or rash; • blurred vision; or • ringing in your ears. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect anaprox? Before taking anaprox tell your doctor if you are taking any of the following drugs: • a blood thinner such as warfarin (Coumadin); • lithium (Eskalith Lithobid); • methotrexate (Rheumatrex Trexall); • diuretics (water pills) such as furosemide (Lasix); • steroids (prednisone and others); • aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as diclofenac (Cataflam Voltaren) etodolac (Lodine) flurbiprofen (Ansaid) indomethacin (Indocin) ketoprofen (Orudis) ketorolac (Toradol) mefenamic acid (Ponstel) meloxicam (Mobic) nabumetone (Relafen) piroxicam (Feldene) and others; or • an ACE inhibitor such as benazepril (Lotensin) captopril (Capoten) fosinopril (Monopril) enalapril (Vasotec) lisinopril (Prinivil Zestril) ramipril (Altace) and others. If you are using any of these drugs you may not be able to use anaprox or you may need dosage adjustments or special tests during treatment. There may be other drugs not listed that can affect anaprox. 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