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Moduretic (Amiloride and Hydrochlorothiazide)

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Moduretic is used for treating fluid retention (edema) and high blood pressure. It may be used alone or with other medicines. Moduretic is a diuretic (water pill) and is a combination of a potassium-sparing diuretic (amiloride) and a thiazide diuretic (hydrochlorothiazide). It works by making the kidneys eliminate sodium (salt) and water from the body which helps to lower blood pressure. The amiloride component helps minimize potassium loss.

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About Moduretic (Amiloride and Hydrochlorothiazide):

Product Type: Blood Pressure

Brand name: Moduretic Generic name: Amiloride and Hydrochlorothiazide Moduretic is used for: Treating fluid retention (edema) and high blood pressure. It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor. Moduretic is a diuretic (water pill) and is a combination of a potassium-sparing diuretic (amiloride) and a thiazide diuretic (hydrochlorothiazide). It works by making the kidneys eliminate sodium (salt) and water from the body which helps to lower blood pressure. The amiloride component helps minimize potassium loss. Do NOT use Moduretic if: • you are allergic to any ingredient in Moduretic or any other sulfonamide (eg sulfamethoxazole) • you are unable to urinate have severely decreased kidney function or high blood potassium • you are taking other potassium-sparing diuretics (eg spironolactone) potassium supplements salt substitutes containing potassium or dofetilide Contact your doctor or health care provider right away if any of these apply to you. Before using Moduretic: Some medical conditions may interact with Moduretic. Tell your doctor or pharmacist if you have any medical conditions especially if any of the following apply to you: • if you are pregnant planning to become pregnant or are breast-feeding • if you are taking any prescription or nonprescription medicine herbal preparation or dietary supplement • if you have allergies to medicines foods or other substances • if you have cirrhosis or liver problems diabetes gout kidney problems or kidney stones asthma heart problems or systemic lupus erythematosus (SLE or lupus) • if you have elevated blood acid low folic acid levels or electrolyte problems or are dehydrated Some MEDICINES MAY INTERACT with Moduretic. Tell your health care provider if you are taking any other medicines especially any of the following: • Potassium-sparing diuretics (eg spironolactone) potassium supplements or salt substitutes containing potassium because high blood potassium levels may occur and cause listlessness confusion abnormal skin sensations of the arms and legs heaviness of limbs slowed heart rate irregular heart rhythm or stopping of the heart • Cholestyramine or colestipol because they may decrease Moduretic's effectiveness • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg indomethacin) because they may decrease Moduretic's effectiveness of Moduretic may be decreased and the risk of kidney problems may be increased • Barbiturates (eg phenobarbital) certain chemotherapy medicines corticosteroids (eg prednisone) digoxin dofetilide ketanserin narcotic pain medicines (eg codeine) or medicines for high blood pressure because the risk of their side effects may be increased by Moduretic • Diazoxide lithium or nondepolarizing neuromuscular blockers (eg pancuronium) because their actions and the risk of their side effects may be increased by Moduretic • Angiotensin-converting enzyme (ACE) inhibitors (eg enalapril) because the risk of high blood potassium and kidney problems may be increased by Moduretic • Diabetes medicines (eg glipizide) or insulin because their effectiveness may be decreased by Moduretic This may not be a complete list of all interactions that may occur. Ask your health care provider if Moduretic may interact with other medicines that you take. Check with your health care provider before you start stop or change the dose of any medicine. How to use Moduretic: Use Moduretic as directed by your doctor. Check the label on the medicine for exact dosing instructions. • Take Moduretic by mouth with food. • Moduretic may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep try to take your dose before 6 pm. • If you miss a dose of Moduretic take it as soon as possible. If it is almost time for your next dose skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use Moduretic. Important safety information: • Moduretic may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Moduretic with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. • Moduretic may cause dizziness lightheadedness or fainting; alcohol hot weather exercise or fever may increase these effects. To prevent them sit up or stand slowly especially in the morning. Sit or lie down at the first sign of any of these effects. • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms. • Moduretic may cause you to become sunburned more easily. Avoid the sun sunlamps or tanning booths until you know how you react to Moduretic. Use a sunscreen or wear protective clothing if you must be outside for more than a short time. • Tell your doctor or dentist that you take Moduretic before you receive any medical or dental care emergency care or surgery. • Diabetes patients — Moduretic may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. • Lab tests including liver function kidney function lung function blood pressure and fasting blood glucose may be performed while you use Moduretic. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. • Moduretic should not be used in CHILDREN; safety and effectiveness in children have not been confirmed. • PREGNANCY and BREAST-FEEDING: If you become pregnant contact your doctor. You will need to discuss the benefits and risks of using Moduretic while you are pregnant. It is not known if Moduretic is found in breast milk. Do not breast-feed while taking Moduretic. Possible side effects of Moduretic: All medicines may cause side effects but many people have no or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: • Changes in blood sugar; constipation; dizziness; fatigue; headache; inflammation of a salivary gland; loss of appetite; nausea; sensitivity to sunlight; stomach pain; weakness. Seek medical attention right away if any of these SEVERE side effects occur: • Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth face lips or tongue); dry mouth; excessive thirst; impotence; leg or muscle cramps; mental confusion; rapid weak or irregular heartbeat; stomach pain; urination problems; vomiting; yellowing of skin or eyes. This is not a complete list of all side effects that may occur. If you have questions about side effects contact your health care provider. Call your doctor for medical advice about side effects. If OVERDOSE is suspected: Contact 1-800-222-1222 (the American Association of Poison Control Centers) your local poison control center (http://www.aapcc.org) or emergency room immediately. Symptoms may include excessive urination; flushed face; lightheadedness especially upon standing; nausea; vomiting; weakness. Proper storage of Moduretic: Store Moduretic at room temperature between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat moisture and light. Do not store in the bathroom. Keep Moduretic out of the reach of children and away from pets.

Generic Moduretic (Amiloride and Hydrochlorothiazide)

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Before taking anaprox tell your doctor if you are allergic to any drugs or if you have: • a history of heart attack stroke or blood clot; • heart disease congestive heart failure high blood pressure; • a history of stomach ulcers or bleeding; • liver or kidney disease; • asthma; • polyps in your nose; • a bleeding or blood clotting disorder; or • if you smoke. If you have any of these conditions you may not be able to use anaprox or you may need a dosage adjustment or special tests during treatment. FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking anaprox during the last 3 months of pregnancy may result in birth defects. Do not take anaprox during pregnancy unless your doctor has told you to. Naproxen can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. 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Symptoms of a anaprox overdose may include nausea vomiting stomach pain confusion drowsiness black or bloody stools coughing up blood shallow breathing fainting or coma. What should I avoid while taking anaprox? Do not use any other over-the-counter cold allergy or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to anaprox (such as ibuprofen or ketoprofen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin ibuprofen or ketoprofen. Do not drink alcohol while taking anaprox. Alcohol can increase the risk of stomach bleeding caused by anaprox. Avoid prolonged exposure to sunlight. Naproxen may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable. Naproxen side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face lips tongue or throat. Stop taking anaprox and seek medical attention or call your doctor at once if you have any of these serious side effects: • chest pain weakness shortness of breath slurred speech problems with vision or balance; • black bloody or tarry stools; • coughing up blood or vomit that looks like coffee grounds; • swelling or rapid weight gain; • urinating less than usual or not at all; • nausea stomach pain low fever loss of appetite dark urine clay-colored stools jaundice (yellowing of the skin or eyes); • fever sore throat and headache with a severe blistering peeling and red skin rash; • bruising severe tingling numbness pain muscle weakness; or • fever headache neck stiffness chills increased sensitivity to light purple spots on the skin and/or seizure (convulsions). 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