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Sporanox (Itraconazole) is an antifungal agent used to treat fungal infections.
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About Sporanox (Itraconazole):
Product Type: Anti Fungal
Brand name: Sporanox
Generic name: Itraconazole
What is the most important information I should know about Sporanox?
• Do not take Sporanox if you are taking astemizole (Hismanal) cisapride (Propulsid) pimozide (Orap) triazolam (Halcion) midazolam (Versed) lovastatin (Mevacor) simvastatin (Zocor) or quinidine (Cardioquin Quinora Quinidex Quinaglute Quin-Release Quin-G). Combined with these drugs Sporanox could cause serious even fatal problems.
• In rare cases Sporanox has caused severe liver damage sometimes resulting in death. Notify your doctor immediately if you develop nausea vomiting abdominal pain unusual fatigue loss of appetite yellow skin or eyes itching dark urine or clay colored stools. These symptoms may be early signs of liver damage.
• In rare cases Sporanox has been associated with the onset of congestive heart failure (CHF). Do not take Sporanox without first talking to your doctor if you have CHF or a history of CHF; other heart or heart valve disease; a lung disease such as chronic obstructive pulmonary disease; or significant swelling or water retention (edema). Contact your doctor if you develop symptoms that may indicate CHF including shortness of breath chest pain or swelling during treatment with Sporanox.
• Take all of the Sporanox that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.
What is Sporanox?
• Sporanox is an antifungal medication. It is like an antibiotic but is used to treat fungal infections.
• Sporanox is used to treat fungal infections in the lungs in the central nervous system in other parts of the body as well as serious fungal infections of the skin and nails. The Sporanox oral solution is used to treat yeast infections of the mouth throat and esophagus.
• Sporanox may also be used for purposes other than those listed in this medication guide.
What should I discuss with my healthcare provider before taking Sporanox?
• Do not take Sporanox if you are taking any of the following drugs:
astemizole (Hismanal);
cisapride (Propulsid);
pimozide (Orap);
quinidine (Cardioquin Quinora Quinidex Quinaglute Quin-Release Quin-G);
midazolam (Versed) or triazolam (Halcion); or
lovastatin (Mevacor) or simvastatin (Zocor).
• Dangerous or life-threatening events may occur if Sporanox is taken with any of the medicines listed above.
• In rare cases Sporanox has been associated with the onset of congestive heart failure (CHF). Do not take Sporanox without first talking to your doctor if you have CHF or a history of CHF; other heart or heart valve disease; a lung disease such as chronic obstructive pulmonary disease; or significant swelling or water retention (edema). Contact your doctor if you develop symptoms that may indicate CHF including shortness of breath chest pain or swelling during treatment with Sporanox.
• Before taking Sporanox tell your doctor if you have
liver disease; or
achlorhydria (decreased stomach acid production) or if you take antacids stomach acid reducers or stomach ulcer medicines.
• You may not be able to take Sporanox or you may require a dosage adjustment special monitoring or special directions for use during your treatment.
• Sporanox is in the FDA pregnancy category C. This means that it is not known whether Sporanox will be harmful to an unborn baby. Effective contraception is recommended for any woman who could potentially become pregnant during treatment with Sporanox and for 2 months following the end of treatment. Do not take this medication without first talking to your doctor if you are pregnant.
• Sporanox passes into breast milk and may affect a nursing infant. Do not take Sporanox without first talking to your doctor if you are breast-feeding a baby.
How should I take Sporanox?
• Take Sporanox exactly as directed by your doctor. If you do not understand these instructions ask your pharmacist nurse or doctor to explain them to you.
• Take each capsule with a full glass of water.
• Take Sporanox capsules after a full meal to increase absorption in your stomach.
• To treat yeast infections of the mouth throat or esophagus the oral solution should be swished vigorously in the mouth for several seconds then swallowed. Take the oral solution without food if possible.
• Sporanox capsules and oral solution are different preparations and cannot be used interchangeably.
• Take all of the Sporanox that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.
• Grapefruit and grapefruit juice may interact with Sporanox. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.
• Store Sporanox at room temperature away from moisture and heat.
What happens if I miss a dose?
• Take the missed dose as soon as you remember. If it is almost time for the next dose skip the dose you missed and take only the next regularly scheduled dose as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.
What happens if I overdose?
• Seek emergency medical attention if an overdose is suspected.
• Symptoms of an Sporanox overdose are not well known but might include dizziness ringing in the ears headache nausea vomiting diarrhea and abdominal pain.
What should I avoid while taking Sporanox?
• Use alcohol with moderation while taking Sporanox. Alcohol and Sporanox can both affect the liver.
• Use caution when driving or performing other hazardous activities. Sporanox may cause dizziness. If you experience dizziness avoid these activities.
• Grapefruit and grapefruit juice may interact with Sporanox. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.
What are the possible side effects of Sporanox?
• If you experience any of the following serious side effects stop taking Sporanox and seek emergency medical attention or notify your doctor immediately:
an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips tongue or face; or hives);
liver damage (pale stools yellowish skin or eyes abdominal pain unusual fatigue or dark urine);
symptoms of congestive heart failure including shortness of breath chest pain or swelling; or
nerve pain numbness or tingling.
• Other less serious side effects may be more likely to occur. If you experience any of the following side effects continue taking Sporanox and talk to your doctor:
nausea vomiting or diarrhea;
headache;
dizziness;
fatigue; or
itching or a rash.
• Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
What other drugs will affect Sporanox?
• Do not take Sporanox if you are taking any of the following drugs:
astemizole (Hismanal);
cisapride (Propulsid);
pimozide (Orap);
quinidine (Cardioquin Quinora Quinidex Quinaglute Quin-Release Quin-G);
midazolam (Versed) or triazolam (Halcion); or
lovastatin (Mevacor) or simvastatin (Zocor).
• Dangerous or life-threatening events may occur if Sporanox is taken with any of the medicines listed above.
• Before taking Sporanox tell your doctor if you are taking any other medicines especially any of the following:
digoxin (Lanoxin Lanoxicaps);
carbamazepine (Tegretol others) or phenytoin (Dilantin others);
rifabutin (Mycobutin) or rifampin (Rifadin Rimactane);
busulfan (Myleran) docetaxel (Taxotere) vinblastine sulfate (Velban) vincristine sulfate (Oncovin) or vinorelbine (Navelbine);
trimetrexate (Neutrexin);
alprazolam (Xanax) or diazepam (Valium);
verapamil (Isoptin Verelan Calan Covera-HS) amlodipine (Norvasc) felodipine (Plendil) isradipine (DynaCirc) nicardipine (Cardene) nifedipine (Adalat Procardia) nimodipine (Nimotop) or nisoldipine (Sular);
atorvastatin (Lipitor) or cerivastatin (Baycol);
tacrolimus (Prograf);
sirolimus (Rapamune);
cyclosporine (Sandimmune Neoral);
glipizide (Glucotrol) glyburide (Diabeta Micronase Glynase) tolbutamide (Orinase) tolazamide (Tolinase) chlorpropamide (Diabinese) and others;
indinavir (Crixivan) ritonavir (Norvir) or saquinavir (Fortovase Invirase);
buspirone (Buspar);
antacids;
cimetidine (Tagamet Tagamet HB) nizatidine (Axid Axid AR) famotidine (Pepcid Pepcid AC) or ranitidine (Zantac Zantac 75);
omeprazole (Prilosec) lansoprazole (Prevacid) or rabeprazole (Aciphex);
isoniazid (Nydrazid);
nevirapine (Viramune);
methylprednisolone (Medrol others);
clarithromycin (Biaxin); or
warfarin (Coumadin).
• You may not be able to take Sporanox or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
• Drugs other than those listed here may also interact with Sporanox or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines including herbal products
Generic Sporanox (Itraconazole)
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Itraconazole Sporanox

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Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft or CABG). NSAIDs can also increase your risk of serious effects on the stomach or intestines including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects. Do not use this medication if you are allergic to anaprox or if you have a history of allergic reaction to aspirin or other NSAIDs. Before taking anaprox tell your doctor if you are allergic to any drugs or if you have: • a history of heart attack stroke or blood clot; • heart disease congestive heart failure high blood pressure; • a history of stomach ulcers or bleeding; • liver or kidney disease; • asthma; • polyps in your nose; • a bleeding or blood clotting disorder; or • if you smoke. If you have any of these conditions you may not be able to use anaprox or you may need a dosage adjustment or special tests during treatment. FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking anaprox during the last 3 months of pregnancy may result in birth defects. Do not take anaprox during pregnancy unless your doctor has told you to. Naproxen can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medicine to a child younger than 2 years old without the advice of a doctor. How should I take anaprox? Take this medication exactly as directed on the label or as it has been prescribed by your doctor. Do not use the medication in larger amounts or use it for longer than recommended. EC-Naprosyn is a slower-acting form of anaprox and this brand should be used only for treating arthritis or ankylosing spondylitis. Follow your doctor's instructions. Do not crush chew or break an extended-release or enteric-coated tablet. Swallow the pill whole. The extended-release pill is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time. The enteric-coated pill has a special coating to protect your stomach. Breaking the pill could damage this coating. Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose measure the liquid with a marked measuring spoon or medicine cup not with a regular table spoon. If you do not have a dose-measuring device ask your pharmacist for one. If you take anaprox for a long period of time your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. 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